Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkchtm1Cda
Name:	protein kinase C, eta; targeted mutation 1, Kazuhiro Chida
MGI ID:	MGI:2663731
Synonyms:	Prkch-
Gene:	Prkch  Location: Chr12:73631570-73824959 bp, + strand  Genetic Position: Chr12, 30.81 cM, cytoband C3-D1
Alliance:	Prkchtm1Cda page

Germline Transmission:	Earliest citation of germline transmission: J:83498
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the catalytic domain-containing exon 9 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of epidermal proteins. (J:83498)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkch Mutation:	40 strains or lines available

Original:	J:83498 Chida K, et al., Disruption of protein kinase ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. Cancer Res. 2003 May 15;63(10):2404-8
All:	1 reference(s)