About   Help   FAQ
Opn5 Gene Detail
Summary
  • Symbol
    Opn5
  • Name
    opsin 5
  • Synonyms
    Gpr136, Neuropsin, PGR12, TMEM13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2662912
    NCBI Gene: 353344
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr17:42867674-42922286 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.65 cM, cytoband B3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2662912
 protein coding gene Chr17:42867670-42922321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023767
 protein coding gene Chr17:43398597-43457758 (-)
A/J MGP_AJ_G0023725
 protein coding gene Chr17:42429632-42483480 (-)
AKR/J MGP_AKRJ_G0023696
 protein coding gene Chr17:42605060-42665782 (-)
BALB/cJ MGP_BALBcJ_G0023729
 protein coding gene Chr17:42329606-42385211 (-)
C3H/HeJ MGP_C3HHeJ_G0023493
 protein coding gene Chr17:43306162-43359699 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024171
 protein coding gene Chr17:45285098-45345460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021622
 protein coding gene Chr17:39326875-39379487 (-)
CAST/EiJ MGP_CASTEiJ_G0022974
 protein coding gene Chr17:43311205-43368558 (-)
CBA/J MGP_CBAJ_G0023469
 protein coding gene Chr17:46933966-46994127 (-)
DBA/2J MGP_DBA2J_G0023595
 protein coding gene Chr17:41244940-41296412 (-)
FVB/NJ MGP_FVBNJ_G0023562
 protein coding gene Chr17:40801562-40858913 (-)
LP/J MGP_LPJ_G0023676
 protein coding gene Chr17:44059103-44118827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023591
 protein coding gene Chr17:46590383-46654218 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024217
 protein coding gene Chr17:42934413-42994717 (-)
PWK/PhJ MGP_PWKPhJ_G0022719
 protein coding gene Chr17:40490767-40543410 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022534
 protein coding gene Chr17:39869245-39920354 (-)
WSB/EiJ MGP_WSBEiJ_G0023039
 protein coding gene Chr17:43471379-43529862 (-)



Homology
more
  • Human Ortholog
    OPN5, opsin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPN5, opsin 5
  • Synonyms
    GPR136, GRP136, PGR12, TMEM13
  • Links
    NCBI Gene ID: 221391
    neXtProt AC: NX_Q6U736
    UniProt: Q6U736

  • Chr Location
    6p12.3; chr6:47781982-47832780 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to exhibit light/dark entrainment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043972 Ensembl Gene Model | MGI Sequence Detail 54613 C57BL/6J ±  kb
transcript ENSMUST00000068355 Ensembl | MGI Sequence Detail 1906 Not Applicable  
polypeptide ENSMUSP00000063542 Ensembl | MGI Sequence Detail 377 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 34
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:86362 Tarttelin EE, et al., Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. FEBS Lett. 2003 Nov 20;554(3):410-6
  • Latest
    J:296976 Zhang KX, et al., Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Nature. 2020 Sep;585(7825):420-425
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory