Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Miftm1Mky
Name:	macrophage migration inhibitory factor (glycosylation-inhibiting factor); targeted mutation 1, Toshifumi Mikayama
MGI ID:	MGI:2661491
Synonyms:	GIF-, MIF-
Gene:	Mif  Location: Chr10:75695187-75696074 bp, - strand  Genetic Position: Chr10, 38.59 cM, cytoband C1
Alliance:	Miftm1Mky page

Germline Transmission:	Earliest citation of germline transmission: J:75496
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of a 201 bp region spanning parts of exon 1 and intron 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain extracts. (J:75496)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mif Mutation:	21 strains or lines available

Original:	J:75496 Honma N, et al., Deficiency of the macrophage migration inhibitory factor gene has no significant effect on endotoxaemia. Immunology. 2000 May;100(1):84-90
All:	16 reference(s)