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Kbtbd8 Gene Detail
Summary
  • Symbol
    Kbtbd8
  • Name
    kelch repeat and BTB (POZ) domain containing 8
  • Synonyms
    mKIAA1842, SSEC51, SSEC 51, SSEC-51, Takrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661430
    NCBI Gene: 243574
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:95094861-95106774 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661430
 protein coding gene Chr6:95094221-95106774 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031066
 protein coding gene Chr6:96913667-96923326 (+)
A/J MGP_AJ_G0031035
 protein coding gene Chr6:93223312-93233007 (+)
AKR/J MGP_AKRJ_G0030966
 protein coding gene Chr6:95789591-95799249 (+)
BALB/cJ MGP_BALBcJ_G0031046
 protein coding gene Chr6:93174582-93184277 (+)
C3H/HeJ MGP_C3HHeJ_G0030662
 protein coding gene Chr6:88611174-88626173 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031505
 protein coding gene Chr6:99327448-99338560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028671
 protein coding gene Chr6:91176394-91188756 (+)
CAST/EiJ MGP_CASTEiJ_G0030153
 protein coding gene Chr6:95992845-96008121 (+)
CBA/J MGP_CBAJ_G0030732
 protein coding gene Chr6:103132315-103142025 (+)
DBA/2J MGP_DBA2J_G0030885
 protein coding gene Chr6:92370662-92380357 (+)
FVB/NJ MGP_FVBNJ_G0030839
 protein coding gene Chr6:91581093-91593508 (+)
LP/J MGP_LPJ_G0030965
 protein coding gene Chr6:96892494-96902208 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030873
 protein coding gene Chr6:107064879-107074546 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031532
 protein coding gene Chr6:95664652-95678341 (+)
PWK/PhJ MGP_PWKPhJ_G0029869
 protein coding gene Chr6:91393275-91403147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029698
 protein coding gene Chr6:94602203-94614366 (+)
WSB/EiJ MGP_WSBEiJ_G0030237
 protein coding gene Chr6:96125766-96141348 (+)



Homology
more
  • Human Ortholog
    KBTBD8, kelch repeat and BTB domain containing 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KBTBD8, kelch repeat and BTB domain containing 8
  • Synonyms
    TAKRP, TA-KRP
  • Links
    NCBI Gene ID: 84541
    neXtProt AC: NX_Q8NFY9
    UniProt: Q8NFY9

  • Chr Location
    3p14.1; chr3:66998307-67011210 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    36
  • cDNA Data
    68
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243574 NCBI Gene Model | MGI Sequence Detail 11914 C57BL/6J ±  kb
    transcript NM_001008785 RefSeq | MGI Sequence Detail 4732 C57BL/6  
    polypeptide Q3UQV5 UniProt | EBI | MGI Sequence Detail 599 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 68

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2141580
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory