Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gdf6tm1Kng
Name:	growth differentiation factor 6; targeted mutation 1, David M Kingsley
MGI ID:	MGI:2661063
Synonyms:	Gdf6-
Gene:	Gdf6  Location: Chr4:9844372-9862345 bp, + strand  Genetic Position: Chr4, 4.35 cM
Alliance:	Gdf6tm1Kng page

Germline Transmission:	Earliest citation of germline transmission: J:83132
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the entire mature signalling region and 120 amino acids of the pro region. (J:83132)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gdf6 Mutation:	25 strains or lines available

Original:	J:83132 Settle SH Jr, et al., Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol. 2003 Feb 1;254(1):116-30
All:	5 reference(s)