Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Tial1tm1Mst Name: Tia1 cytotoxic granule-associated RNA binding protein-like 1; targeted mutation 1, Michel Streuli MGI ID: MGI:2660803 Synonyms: tiar- Gene: Tial1  Location: Chr7:128041501-128063441 bp, - strand  Genetic Position: Chr7, 70.2 cM, cytoband F4 Alliance: Tial1tm1Mst page

Lack of germ cells in Tial1tm1Mst/Tial1tm1Mst mouse testes and ovaries Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:46239
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 5' portion of exon 6 was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of extracts from homozygous mutant ES cells. (J:46239)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tial1 Mutation:	21 strains or lines available

Original:	J:46239 Beck ARP, et al., RNA-binding protein TIAR is essential for primordial germ cell development. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2331-6
All:	3 reference(s)