Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Clpstm1Lowe
Name:	colipase, pancreatic; targeted mutation 1, Mark E Lowe
MGI ID:	MGI:2660767
Synonyms:	Clps-
Gene:	Clps  Location: Chr17:28777184-28779740 bp, - strand  Genetic Position: Chr17, 14.76 cM, cytoband B1
Alliance:	Clpstm1Lowe page

Germline Transmission:	Earliest citation of germline transmission: J:75167
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 1 and part of intron 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analysis of samples from the pancreas, stomach, and small intestines. (J:75167)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clps Mutation:	11 strains or lines available

Original:	J:75167 D'Agostino D, et al., Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem. 2002 Mar 1;277(9):7170-7
All:	2 reference(s)