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Tlr9tm1Aki
Targeted Allele Detail
Summary
Symbol: Tlr9tm1Aki
Name: toll-like receptor 9; targeted mutation 1, Shizuo Akira
MGI ID: MGI:2660562
Synonyms: Tlr9-, TLR9 KO
Gene: Tlr9  Location: Chr9:106099797-106104075 bp, + strand  Genetic Position: Chr9, 57.46 cM
Alliance: Tlr9tm1Aki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66049
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.0 kb fragment of the gene encoding a part of a leucine-rich repeat domain was replaced with a neomycin resistance cassette. Northern blot analysis demonstrated that a mutated transcript was expressed from this allele, but this transcript is not expected to produce a functional protein. (J:66049)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Tlr9 Mutation:  65 strains or lines available
References
Original:  J:66049 Hemmi H, et al., A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5
All:  436 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory