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Mocs1tm1Jre
Targeted Allele Detail
Summary
Symbol: Mocs1tm1Jre
Name: molybdenum cofactor synthesis 1; targeted mutation 1, Jochen Reiss
MGI ID: MGI:2659140
Synonyms: Moco-deficient, MOCS1 -
Gene: Mocs1  Location: Chr17:49735390-49762463 bp, + strand  Genetic Position: Chr17, 25.45 cM, cytoband C
Alliance: Mocs1tm1Jre page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80807
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exon 3 and flanking sequences. Northern blot analysis on liver RNA derived from homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:80807)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mocs1 Mutation:  27 strains or lines available
References
Original:  J:80807 Lee HJ, et al., Molybdenum cofactor-deficient mice resemble the phenotype of human patients. Hum Mol Genet. 2002 Dec 15;11(26):3309-17
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory