Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Jag2tm1Grid
Name:	jagged 2; targeted mutation 1, Tom Gridley
MGI ID:	MGI:2657215
Synonyms:	Jag2-, Jag2deltaDSL
Gene:	Jag2  Location: Chr12:112871439-112893396 bp, - strand  Genetic Position: Chr12, 61.37 cM
Alliance:	Jag2tm1Grid page

Germline Transmission:	Earliest citation of germline transmission: J:46930
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of a 5 kb region with a PGK-neo cassette via recombination resulting in deletion of the DSL domain and half of the first EGF repeat. The absence of the DSL domain-containing sequence was confirmed by Southern blot analysis. (J:46930) Inheritance:    Not Specified

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jag2 Mutation:	44 strains or lines available

Original:	J:46930 Jiang R, et al., Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 1998 Apr 1;12(7):1046-57
All:	16 reference(s)