Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trpc2tm1Dlc
Name:	transient receptor potential cation channel, subfamily C, member 2; targeted mutation 1, Catherine Dulac
MGI ID:	MGI:2657154
Synonyms:	TRP2-
Gene:	Trpc2  Location: Chr7:101732323-101745603 bp, + strand  Genetic Position: Chr7, 54.71 cM, cytoband F1
Alliance:	Trpc2tm1Dlc page

Germline Transmission:	Earliest citation of germline transmission: J:74988
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons encoding transmembrane domains 4 and 5, part of a putative channel pore, and a conserved sequence motif (EWKFAR), with a floxed PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of vomeronasal organ extracts. (J:74988)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpc2 Mutation:	98 strains or lines available

Original:	J:74988 Stowers L, et al., Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science. 2002 Feb 22;295(5559):1493-500
All:	28 reference(s)