Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Socs1tm3.1Wehi
Name:	suppressor of cytokine signaling 1; targeted mutation 3.1, Walter and Eliza Hall Institute of Medical Research
MGI ID:	MGI:2656956
Synonyms:	SOCS-1CMV-lox
Gene:	Socs1  Location: Chr16:10601672-10603400 bp, - strand  Genetic Position: Chr16, 5.81 cM
Alliance:	Socs1tm3.1Wehi page

Germline Transmission:	Earliest citation of germline transmission: J:83009
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A null allele was generated by removing a floxed fragment containing the entire gene by cre-mediated recombination in the germline. Human CD4-polyA and an FRT flanked hygro cassette remained after excision. (J:83009)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Socs1 Mutation:	29 strains or lines available

Original:	J:83009 Chong MM, et al., Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity. 2003 Apr;18(4):475-87
All:	1 reference(s)