Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Selenoptm1Rfb
Name:	selenoprotein P; targeted mutation 1, Raymond F Burk
MGI ID:	MGI:2656912
Synonyms:	Sepp-
Gene:	Selenop  Location: Chr15:3300249-3309992 bp, + strand  Genetic Position: Chr15, 1.84 cM
Alliance:	Selenoptm1Rfb page

Germline Transmission:	Earliest citation of germline transmission: J:82921
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. The neo cassette carries stop codons in all 3 reading frames. Protein product was undetectable by Western blot and radioimmunoassay of plasma samples from homozygous mutant animals. (J:82921)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Selenop Mutation:	22 strains or lines available

Original:	J:82921 Hill KE, et al., Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem. 2003 Apr 18;278(16):13640-6
All:	33 reference(s)