Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl2a1atm1Prys
Name:	B cell leukemia/lymphoma 2 related protein A1a; targeted mutation 1, Michael Prystowsky
MGI ID:	MGI:2656326
Synonyms:	A1-a-, Bcl2a1atm1Orlf
Gene:	Bcl2a1a  Location: Chr9:88838973-88844469 bp, + strand  Genetic Position: Chr9, 47.24 cM
Alliance:	Bcl2a1atm1Prys page

Germline Transmission:	Earliest citation of germline transmission: J:74478
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of bone marrow macrophage RNA from homozygous mutant animals. (J:74478)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2a1a Mutation:	14 strains or lines available

Original:	J:74478 Orlofsky A, et al., Deficiency in the Anti-Apoptotic Protein A1-a Results in a Diminished Acute Inflammatory Response. J Immunol. 2002 Feb 15;168(4):1840-6
All:	1 reference(s)