Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	St8sia1tm1Kfk
Name:	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; targeted mutation 1, Koichi Furukawa
MGI ID:	MGI:2656251
Synonyms:	GD3s-KO, Sia-T-
Gene:	St8sia1  Location: Chr6:142767271-142910178 bp, - strand  Genetic Position: Chr6, 74.78 cM
Alliance:	St8sia1tm1Kfk page

Germline Transmission:	Earliest citation of germline transmission: J:73818
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 via homologous recombination. Enzyme activity was absent from brain tissue extracts derived from homozygous mutant animals. (J:73818)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any St8sia1 Mutation:	28 strains or lines available

Original:	J:73818 Okada M, et al., b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem. 2002 Jan 18;277(3):1633-6
All:	18 reference(s)