Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrm1tm1Jwe
Name:	cholinergic receptor, muscarinic 1, CNS; targeted mutation 1, Jurgen Wess
MGI ID:	MGI:2655332
Synonyms:	M1 -, M1R-, mAChR1-
Gene:	Chrm1  Location: Chr19:8641369-8660970 bp, + strand  Genetic Position: Chr19, 5.44 cM
Alliance:	Chrm1tm1Jwe page

Germline Transmission:	Earliest citation of germline transmission: J:74588
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced a 0.28 kb genomic fragment that contained the translation start site and the region coding for the first 54 amino acids of the encoded protein. Immunoprecipitation studies demonstrated that no detectable protein was present in membranes prepared from hippocampus of homozygous mice. (J:74588)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrm1 Mutation:	26 strains or lines available

Original:	J:74588 Fisahn A, et al., Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron. 2002 Feb 14;33(4):615-24
All:	40 reference(s)