Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfaip6tm1Cful
Name:	tumor necrosis factor alpha induced protein 6; targeted mutation 1, Csaba Fulop
MGI ID:	MGI:2654926
Synonyms:	Tnfip6-/-
Gene:	Tnfaip6  Location: Chr2:51928125-51946693 bp, + strand  Genetic Position: Chr2, 29.98 cM
Alliance:	Tnfaip6tm1Cful page

Germline Transmission:	Earliest citation of germline transmission: J:82539
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was disrupted by a neomycin selection cassette inserted via homologous recombination. Neither transcript nor protein was detected by RT-PCR and Western blot analysis of homozygous mutant embyronic fibroblasts, with and without Tnfa stimulation. (J:82539)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfaip6 Mutation:	22 strains or lines available

Original:	J:82539 Fulop C, et al., Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Development. 2003 May;130(10):2253-61
All:	15 reference(s)