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Kcnmb1tm1Pong
Targeted Allele Detail
Summary
Symbol: Kcnmb1tm1Pong
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 1; targeted mutation 1, Olaf Pongs
MGI ID: MGI:2654278
Synonyms: BKbeta1-
Gene: Kcnmb1  Location: Chr11:33913013-33923641 bp, + strand  Genetic Position: Chr11, 19.32 cM
Alliance: Kcnmb1tm1Pong page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82471
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsGene targeting was used to flank exon 1 with a floxed PGK-neo cassette on one side and a loxP site on the other side. Correctly targeted ES cells were transiently transfected with a cre-recombinase plasmid to delete exon 1. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and RT-PCR analysis. (J:82471)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnmb1 Mutation:  14 strains or lines available
References
Original:  J:82471 Pluger S, et al., Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure. Circ Res. 2000 Nov 24;87(11):E53-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory