Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cav1tm1Tt
Name:	caveolin 1, caveolae protein; targeted mutation 1, Timothy C Thompson
MGI ID:	MGI:2654177
Synonyms:	cav-1-, Cav1-
Gene:	Cav1  Location: Chr6:17306387-17341323 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Alliance:	Cav1tm1Tt page

Germline Transmission:	Earliest citation of germline transmission: J:82490
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette and loxP site were introduced flanking exon 2 via homologous recombination. Transient expression of cre-recombinase in correctly targeted ES cells resulted in deletion of exon 2 and the neo cassette leaving behind a single loxP site. Absence of protein product in homozygous mutant animals was confirmed by Western blot anlysis of heart, spleen, and lung extracts. (J:82490)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:	29 strains or lines available

Original:	J:82490 Cao G, et al., Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol. 2003 Apr;162(4):1241-8
All:	7 reference(s)