Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ddit3tm1Dron
Name:	DNA-damage inducible transcript 3; targeted mutation 1, David Ron
MGI ID:	MGI:2654034
Synonyms:	chop-, Chop null
Gene:	Ddit3  Location: Chr10:127126662-127132160 bp, + strand  Genetic Position: Chr10, 74.5 cM
Alliance:	Ddit3tm1Dron page

Germline Transmission:	Earliest citation of germline transmission: J:52729
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced the coding region in parts of exons 3 and 4. Northern blot analyses did not detect transcript in MEFs from homozygous mutant E13.5 embryos. (J:52729)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ddit3 Mutation:	20 strains or lines available

Original:	J:52729 Zinszner H, et al., CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998 Apr 1;12(7):982-95
All:	37 reference(s)