Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Ppp1r3atm1Adpr
Name:	protein phosphatase 1, regulatory subunit 3A; targeted mutation 1, Anna A DePaoli-Roach
MGI ID:	MGI:2653989
Synonyms:	RGL null
Gene:	Ppp1r3a  Location: Chr6:14713976-14755273 bp, - strand  Genetic Position: Chr6, 6.31 cM, cytoband A2
Alliance:	Ppp1r3atm1Adpr page

Germline Transmission:	Earliest citation of germline transmission: J:68370
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1, which encodes the first 262 amino acids, was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included the sequence encoding the C1 and glycogen binding domains as well as the Ser48 and Ser67 phosphorylation sites. The absence of normal protein was shown by Western blot analysis of homozygous skeletal and cardiac muscle. (J:68370)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp1r3a Mutation:	57 strains or lines available

Original:	J:68370 Suzuki Y, et al., Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol. 2001 Apr;21(8):2683-94
All:	4 reference(s)