About   Help   FAQ
Nr1h2tm1.1Gstr
Targeted Allele Detail
Summary
Symbol: Nr1h2tm1.1Gstr
Name: nuclear receptor subfamily 1, group H, member 2; targeted mutation 1.1, Gertrud Schuster
MGI ID: MGI:2653342
Synonyms: LXRbeta-
Gene: Nr1h2  Location: Chr7:44199040-44203375 bp, - strand  Genetic Position: Chr7, 28.83 cM
Alliance: Nr1h2tm1.1Gstr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82096
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is derived from Nr1hrtm1Gstr. Exons 5 and 6 were deleted by mating Nr1h2tm1Gstr animals to cre deleter strain TgN(CMV-cre)1Cgn. Northern blot analysis of liver RNA from homozygous mutant animals did not detect gene transcripts. (J:82096)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Nr1h2tm1.1Gstr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h2 Mutation:  26 strains or lines available
References
Original:  J:82096 Alberti S, et al., Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001 Mar;107(5):565-73
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory