Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Cdontm1Rsk
Name:	cell adhesion molecule-related/down-regulated by oncogenes; targeted mutation 1, Robert S Krauss
MGI ID:	MGI:2653120
Synonyms:	Cdo-, CdonlacZ-1
Gene:	Cdon  Location: Chr9:35332836-35418948 bp, + strand  Genetic Position: Chr9, 20.24 cM
Alliance:	Cdontm1Rsk page

Germline Transmission:	Earliest citation of germline transmission: J:82221
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first coding exon was included in a 742 bp region deleted via homologous recombination. The targeting vector also contained an IRES-lacZ-neo cassette that replaced the 3' portion of exon 3. Endogenous protein was undetected by Western blot analysis of homozygous mutant mice. No beta-galactosidase activity was detected by staining. (J:82221)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdon Mutation:	66 strains or lines available

Original:	J:82221 Cole F, et al., Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon. Curr Biol. 2003 Mar 4;13(5):411-5
All:	27 reference(s)