Ndntm1Mus
Targeted Allele Detail
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Symbol: |
Ndntm1Mus |
Name: |
necdin, MAGE family member; targeted mutation 1, Francoise Muscatelli |
MGI ID: |
MGI:2653059 |
Gene: |
Ndn Location: Chr7:61998025-61999676 bp, + strand Genetic Position: Chr7, 34.36 cM, cytoband C
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Alliance: |
Ndntm1Mus page
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Germline Transmission: |
Earliest citation of germline transmission:
J:66557
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Parent Cell Line: |
CK35 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The 5' two-thirds of the endogenous coding region was replaced with a floxed neo cassette inserted by homologous recombination. Normal transcript was undetected by Northern blot and RT-PCR analyses of both homozygous mutant mice and heterozygous mice carrying a paternal mutant allele. An absence of protein was verified in these mice by Western blot analysis of brain tissue.
(J:66557)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ndn Mutation: |
18 strains or lines available
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Original: |
J:66557 Muscatelli F, et al., Disruption of the mouse necdin gene results in hypothalamic and behavioral alterations reminiscent of the human prader-willi syndrome. Hum Mol Genet. 2000 Dec 12;9(20):3101-10 |
All: |
3 reference(s) |
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