Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-DMatm1Lkrl
Name:	histocompatibility 2, class II, locus DMa; targeted mutation 1, Lars Karlsson
MGI ID:	MGI:2652160
Synonyms:	H2-DM-, H2-M-
Gene:	H2-DMa  Location: Chr17:34338667-34358075 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-DMatm1Lkrl page

Germline Transmission:	Earliest citation of germline transmission: J:31786
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 2 was disrupted by a neomycin selection cassette inserted by homologous recombination. H2-DM heterodimers were undetected in splenocytes obtained from homozygous mutant mice. (J:31786)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H2-DMa Mutation:	27 strains or lines available

Original:	J:31786 Fung-Leung WP, et al., Antigen presentation and T cell development in H2-M-deficient mice. Science. 1996 Mar 1;271(5253):1278-81
All:	6 reference(s)