Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkacbtm2Gsm
Name:	protein kinase, cAMP dependent, catalytic, beta; targeted mutation 2, G Stanley McKnight
MGI ID:	MGI:2651519
Synonyms:	C beta all-
Gene:	Prkacb  Location: Chr3:146435334-146518691 bp, - strand  Genetic Position: Chr3, 72.28 cM, cytoband H3
Alliance:	Prkacbtm2Gsm page

Germline Transmission:	Earliest citation of germline transmission: J:78451
Parent Cell Line:	REK2 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis indicated an absence of all three isoforms in homozygous mutant mice. (J:78451)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkacb Mutation:	29 strains or lines available

Original:	J:78451 Howe DG, et al., Molecular and Behavioral Effects of a Null Mutation in All PKA Cbeta Isoforms. Mol Cell Neurosci. 2002 Jul;20(3):515-24
All:	3 reference(s)