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Atp1a1tm1Ling
Targeted Allele Detail
Summary
Symbol: Atp1a1tm1Ling
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide; targeted mutation 1, Jerry B Lingrel
MGI ID: MGI:2451290
Synonyms: alpha1-
Gene: Atp1a1  Location: Chr3:101483535-101512000 bp, - strand  Genetic Position: Chr3, 44.3 cM, cytoband F3
Alliance: Atp1a1tm1Ling page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55191
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 15 through 18 were replaced with an hprt cassette via homologous recombination. Both alpha 1 transcript and protein levels were reduced by ~40% in heterozygous mutant hearts. An aberrant alpha 1 transcript was detected but was not expected to produce a functional protein. (J:55191)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a1 Mutation:  59 strains or lines available
References
Original:  J:55191 James PF, et al., Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell. 1999 May;3(5):555-63
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory