Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tab2tm1Aki
Name:	TGF-beta activated kinase 1/MAP3K7 binding protein 2; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:2450936
Synonyms:	TAB2-
Gene:	Tab2  Location: Chr10:7781417-7831994 bp, - strand  Genetic Position: Chr10, 2.56 cM
Alliance:	Tab2tm1Aki page

Germline Transmission:	Earliest citation of germline transmission: J:81816
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Flanking loxP sites were introduced to the large exon and a floxed neo cassette was inserted into the upstream intron. Transient expression of cre recombinase in correctly targeted ES cells resulted in deletion of the floxed neo cassette leaving behind loxP sites flanking the large exon. Mutant animals were then mated to cre deleter strain Tg(ACTB-cre)13Miya to generate null animals. (J:81816)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tab2 Mutation:	31 strains or lines available

Original:	J:81816 Sanjo H, et al., TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol. 2003 Feb;23(4):1231-8
All:	3 reference(s)