Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ube2atm1Agr
Name:	ubiquitin-conjugating enzyme E2A; targeted mutation 1, J Anton Grootegoed
MGI ID:	MGI:2450874
Synonyms:	HR6A-, mHR6A-
Gene:	Ube2a  Location: ChrX:36137948-36147875 bp, + strand  Genetic Position: ChrX, 21.28 cM
Alliance:	Ube2atm1Agr page

Germline Transmission:	Earliest citation of germline transmission: J:81811
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The ORF was disrupted immediately after the ATG as a neo was inserted in place of sequence encoding amino acids 3-14 in exon 1. PCR confirmed recombination in mutant mice and RT-PCR indicated lack of transcript in mouse testis. (J:91848)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ube2a Mutation:	6 strains or lines available

Original:	J:81811 Baarends WM, et al., Loss of HR6B Ubiquitin-Conjugating Activity Results in Damaged Synaptonemal Complex Structure and Increased Crossing-Over Frequency during the Male Meiotic Prophase. Mol Cell Biol. 2003 Feb;23(4):1151-62
All:	3 reference(s)