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Ifnl3 Gene Detail
Summary
  • Symbol
    Ifnl3
  • Name
    interferon lambda 3
  • Synonyms
    IFL-1, Il28, Il28b, INF-lambda
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450574
    NCBI Gene: 338374
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:28222261-28223747 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450574
 protein coding gene Chr7:28222251-28223826 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031949
 protein coding gene Chr7:27304997-27306361 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0031858
 protein coding gene Chr7:27319225-27321024 (-)
BALB/cJ MGP_BALBcJ_G0031933
 protein coding gene Chr7:26794364-26796083 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0032399
 protein coding gene Chr7:28178914-28185134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029451
 protein coding gene Chr7:27674745-27708581 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031618
 protein coding gene Chr7:29450644-29452145 (-)
DBA/2J MGP_DBA2J_G0031771
 protein coding gene Chr7:26398003-26399802 (-)
FVB/NJ MGP_FVBNJ_G0031728
 protein coding gene Chr7:26470485-26472260 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031763
 protein coding gene Chr7:28947835-28949604 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032428
 protein coding gene Chr7:26771855-26809473 (-)
PWK/PhJ MGP_PWKPhJ_G0030713
 protein coding gene Chr7:21371137-21405538 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031097
 protein coding gene Chr7:27116246-27155729 (-)



Homology
more
  • Human Ortholog
    IFNL1, interferon lambda 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNL1, interferon lambda 1
  • Synonyms
    IL29, IL-29
  • Links
    NCBI Gene ID: 282618
    neXtProt AC: NX_Q8IU54
    UniProt: Q8IU54

  • Chr Location
    19q13.2; chr19:39296407-39298673 (+)  GRCh38
  • Human Ortholog
    IFNL2, interferon lambda 2
  • Synonyms
    IFNL2a, IFNL3a, IL28A, IL-28A
  • Links
    NCBI Gene ID: 282616
    neXtProt AC: NX_Q8IZJ0
    UniProt: Q8IZJ0

  • Chr Location
    19q13.2; chr19:39268396-39270188 (+)  GRCh38
  • Human Ortholog
    IFNL3, interferon lambda 3
  • Synonyms
    IFN-lambda-3, IFN-lambda-4, IL28B, IL-28B, IL28C, IL-28C
  • Links
    NCBI Gene ID: 282617
    neXtProt AC: NX_Q8IZI9
    UniProt: Q8IZI9

  • Chr Location
    19q13.2; chr19:39243455-39245250 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human IFNL1,IFNL3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060747 Ensembl Gene Model | MGI Sequence Detail 1487 C57BL/6J ±  kb
    transcript ENSMUST00000078364 Ensembl | MGI Sequence Detail 582 Not Applicable  
    polypeptide ENSMUSP00000077473 Ensembl | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR029177 Interferon lambda
      IPR038326 Interferon lambda superfamily
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 35
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
    • Latest
      J:340288 Ingle H, et al., IFN-lambda derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus. Sci Adv. 2023 Sep 15;9(37):eadi2562
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory