Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Chattm1Fhg
Name:	choline acetyltransferase; targeted mutation 1, Fred H Gage
MGI ID:	MGI:2450310
Synonyms:	ChAT(-)
Gene:	Chat  Location: Chr14:32130160-32187866 bp, - strand  Genetic Position: Chr14, 19.4 cM
Alliance:	Chattm1Fhg page

Germline Transmission:	Earliest citation of germline transmission: J:81738
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 11, 12, and 13 were replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by immunostaining of the basal forebrain of homozygous mutant embryos. Assays of the brain stem, spinal cord, and septum showed an absence of endogenous activity. (J:81738) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chat Mutation:	57 strains or lines available

Original:	J:81738 Brandon EP, et al., Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci. 2003 Jan 15;23(2):539-49
All:	11 reference(s)