S100a9tm1Nck
Targeted Allele Detail
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| Symbol: |
S100a9tm1Nck |
| Name: |
S100 calcium binding protein A9 (calgranulin B); targeted mutation 1, Wolfgang Nacken |
| MGI ID: |
MGI:2450165 |
| Synonyms: |
Mrp14- |
| Gene: |
S100a9 Location: Chr3:90599939-90603028 bp, - strand Genetic Position: Chr3, 39.91 cM, cytoband F1-F2
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| Alliance: |
S100a9tm1Nck page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:81642
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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S100a9tm1Nck involves 1 genes/genome features (S100a8)
View all
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Mutation details: A 769 bp fragment encompassing exon 2 and flanking intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The translational start codon was included in the deleted region. Transcript was undetected by Northern blot and RT-PCR analyses of various tissues obtained from homozygous mutant mice. The absence of protein was indicated by flow cytometric, Western blot, and immunostaining analyses. S100A and S100A8 proteins are not detected in peripheral leukocytes.
(J:81642)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any S100a9 Mutation: |
15 strains or lines available
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| Original: |
J:81642 Manitz MP, et al., Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol Cell Biol. 2003 Feb;23(3):1034-43 |
| All: |
39 reference(s) |
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Analysis Tools
