Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gzmatm1Simn
Name:	granzyme A; targeted mutation 1, Markus M Simon
MGI ID:	MGI:2449926
Synonyms:	GrzA-, gzm A-, gzmA-
Gene:	Gzma  Location: Chr13:113230359-113237515 bp, - strand  Genetic Position: Chr13, 63.93 cM, cytoband D
Alliance:	Gzmatm1Simn page

Germline Transmission:	Earliest citation of germline transmission: J:28773
Parent Cell Line:	BL/6-III (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 4 by homologous recombination. Western blot analysis confirmed the absence of protein product and cytochemical analysis demonstrated the absence of enzyme activity in cytotoxic T cells in homozygous mutant animals. (J:28773)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Gzma Mutation:	33 strains or lines available

Original:	J:28773 Ebnet K, et al., Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO J. 1995 Sep 1;14(17):4230-9
All:	53 reference(s)