Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gfi1tm1Sho
Name:	growth factor independent 1 transcription repressor; targeted mutation 1, Stuart Orkin
MGI ID:	MGI:2449921
Synonyms:	Gfi-1-, Gfi1deltaex2-3
Gene:	Gfi1  Location: Chr5:107864521-107873671 bp, - strand  Genetic Position: Chr5, 52.23 cM
Alliance:	Gfi1tm1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:81364
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encompassing the start codon in exon 1 and all of exons 2 and 3 was replaced by a floxed neo cassette inserted by homologous recombination. The neo cassette was subsequently excised via in vivo cre mediated recombination in the germ line. (J:81364)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	22 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfi1 Mutation:	31 strains or lines available

Original:	J:81364 Hock H, et al., Intrinsic requirement for zinc finger transcription factor gfi-1 in neutrophil differentiation. Immunity. 2003 Jan;18(1):109-20
All:	24 reference(s)