Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Unc13atm1Bros
Name:	unc-13 homolog A; targeted mutation 1, Nils Brose
MGI ID:	MGI:2449468
Synonyms:	Munc13-1-deficient, Unc13aKO
Gene:	Unc13a  Location: Chr8:72079356-72124418 bp, - strand  Genetic Position: Chr8, 34.43 cM, cytoband B3.3
Alliance:	Unc13atm1Bros page

Germline Transmission:	Earliest citation of germline transmission: J:56513
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by the replacement of 4 exons encoding amino acids 494-619 (which includes the C1 domain) with a neomycin resistance cassette via homologous recombination. The null allele was confirmed by Western blot analysis using antibodies directed against the extreme N- and C-termini of the protein. (J:56513)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Unc13a Mutation:	74 strains or lines available

Original:	J:56513 Augustin I, et al., Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature. 1999 Jul 29;400(6743):457-61
All:	35 reference(s)