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Adamts10 Gene Detail
Summary
  • Symbol
    Adamts10
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 10
  • Synonyms
    ZnMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449112
    NCBI Gene: 224697
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33743178-33772756 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449112
 protein coding gene Chr17:33742620-33772756 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023529
 protein coding gene Chr17:33442356-33472583 (+)
A/J MGP_AJ_G0023488
 protein coding gene Chr17:32298359-32329009 (+)
AKR/J MGP_AKRJ_G0023454
 protein coding gene Chr17:32674526-32704896 (+)
BALB/cJ MGP_BALBcJ_G0023492
 protein coding gene Chr17:32445663-32475268 (+)
C3H/HeJ MGP_C3HHeJ_G0023255
 protein coding gene Chr17:33011336-33041586 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023936
 protein coding gene Chr17:34668814-34698392 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021409
 protein coding gene Chr17:29829498-29859564 (+)
CAST/EiJ MGP_CASTEiJ_G0022757
 protein coding gene Chr17:33130815-33161398 (+)
CBA/J MGP_CBAJ_G0023231
 protein coding gene Chr17:36073347-36106308 (+)
DBA/2J MGP_DBA2J_G0023360
 protein coding gene Chr17:31689623-31719788 (+)
FVB/NJ MGP_FVBNJ_G0023329
 protein coding gene Chr17:31529294-31559697 (+)
LP/J MGP_LPJ_G0023438
 protein coding gene Chr17:33728046-33757654 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023349
 protein coding gene Chr17:35141401-35171949 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023976
 protein coding gene Chr17:33001024-33030632 (+)
PWK/PhJ MGP_PWKPhJ_G0022505
 protein coding gene Chr17:30580882-30611185 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022321
 protein coding gene Chr17:30972769-31002696 (+)
WSB/EiJ MGP_WSBEiJ_G0022816
 protein coding gene Chr17:33046588-33077742 (+)



Homology
more
  • Human Ortholog
    ADAMTS10, ADAM metallopeptidase with thrombospondin type 1 motif 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS10, ADAM metallopeptidase with thrombospondin type 1 motif 10
  • Synonyms
    ADAM-TS10, ADAMTS-10, WMS, WMS1
  • Links
    NCBI Gene ID: 81794
    neXtProt AC: NX_Q9H324
    UniProt: Q9H324

  • Chr Location
    19p13.2; chr19:8580240-8610735 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adamts10 mouse models; 1 with human ADAMTS10 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a truncation mutation exhibit decreased body weight and length, shorter long bones, thick skin, altered bone development, abnormalities in the ciliary apparatus of the eye, and increased skeletal muscle mass with increased numbers of smaller skeletal muscle fibers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    98
  • cDNA Data
    61
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024299 Ensembl Gene Model | MGI Sequence Detail 29579 C57BL/6J ±  kb
    transcript ENSMUST00000087623 Ensembl | MGI Sequence Detail 4043 Not Applicable  
    polypeptide ENSMUSP00000084905 Ensembl | MGI Sequence Detail 1104 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 2
      cDNA 61
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147031
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:80645 Carninci P, et al., High-efficiency full-length cDNA cloning. Methods Enzymol. 1999;303:19-44
    • Latest
      J:332464 Wu HJ, et al., Optic neuropathy associated with TGFbeta dysregulation in mice with a glaucoma-causative mutation of Adamts10. Matrix Biol. 2022 Oct 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory