Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nrtntm1Jmi
Name:	neurturin; targeted mutation 1, Jeffrey Milbrandt
MGI ID:	MGI:2448936
Synonyms:	Nrtn-, NTN-
Gene:	Nrtn  Location: Chr17:57058325-57064530 bp, - strand  Genetic Position: Chr17, 29.49 cM
Alliance:	Nrtntm1Jmi page

Germline Transmission:	Earliest citation of germline transmission: J:53261
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the entire coding region with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of heart mRNA. (J:53261)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrtn Mutation:	12 strains or lines available

Original:	J:53261 Heuckeroth RO, et al., Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 1999 Feb;22(2):253-63
All:	19 reference(s)