Mepetm1Tbrw
Targeted Allele Detail
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Symbol: |
Mepetm1Tbrw |
Name: |
matrix extracellular phosphoglycoprotein with ASARM motif (bone); targeted mutation 1, Thomas A Brown |
MGI ID: |
MGI:2448895 |
Gene: |
Mepe Location: Chr5:104473195-104486477 bp, + strand Genetic Position: Chr5, 50.68 cM, cytoband E4
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Alliance: |
Mepetm1Tbrw page
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Increased trabecular bone in 1 year old Mepetm1Tbrw/Mepe+ and Mepetm1Tbrw/Mepetm1Tbrw mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:81218
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of exon 3 with a PGK-neo cassette via homologous recombination, resulting in deletion of amino acids 27-441. Northern blot analysis of tibia RNA from homozygous animals did not detect transcripts. Immunohistochemistry of tibia sections from homozygous mutant mice confirmed the absence of gene product.
(J:81218)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mepe Mutation: |
21 strains or lines available
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Original: |
J:81218 Gowen LC, et al., Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass. J Biol Chem. 2003 Jan 17;278(3):1998-2007 |
All: |
5 reference(s) |
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