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H3c14 Gene Detail
Summary
  • Symbol
    H3c14
  • Name
    H3 clustered histone 14
  • Synonyms
    H3-615, H3f2, Hist2h3c1, Hist2h3ca1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448355
    NCBI Gene: 15077
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96154001-96154664 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 41.69 cM, cytoband F1-F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448355
 protein coding gene Chr3:96154001-96155825 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0026768
 protein coding gene Chr3:95812557-95815558 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    H3C13, H3 clustered histone 13
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H3C13, H3 clustered histone 13
  • Synonyms
    H3C14, H3C15, HIST2H3D
  • Links
    NCBI Gene ID: 653604
    neXtProt AC: NX_Q71DI3
    UniProt: Q71DI3

  • Chr Location
    1q21.2; chr1:149813225-149813693 (-)  GRCh38
  • Human Ortholog
    H3C14, H3 clustered histone 14
  • Synonyms
    H3, H3.2, H3C13, H3C15, H3F2, H3FM, H3FN, H3/M, HIST2H3C
  • Links
    NCBI Gene ID: 126961
    neXtProt AC: NX_Q71DI3
    UniProt: Q71DI3

  • Chr Location
    1q21.2; chr1:149840687-149841208 (-)  GRCh38
  • Human Ortholog
    H3C15, H3 clustered histone 15
  • Synonyms
    H3C13, H3C14, H3/n, H3/o, HIST2H3A
  • Links
    NCBI Gene ID: 333932
    neXtProt AC: NX_Q71DI3
    UniProt: Q71DI3

  • Chr Location
    1q21.2; chr1:149852608-149853125 (+)  GRCh38
  • Human Ortholog
    H3C3, H3 clustered histone 3
  • Synonyms
    H3.1, H3/c, H3C1, H3C10, H3C11, H3C12, H3C2, H3C4, H3C6, H3C7, H3C8, H3FC, HIST1H3C
  • Links
    NCBI Gene ID: 8352
    neXtProt AC: NX_P68431
    UniProt: P68431

  • Chr Location
    6p22.2; chr6:26045384-26045869 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from multigenic genotypes
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving H3c14
  • Find Mice (IMSR)
    7 strains or lines available
A homozygous point mutation causes microphthalmia (resulting from abnormal cornea, lens and retina development), increased locomotor activity, rearing and body temperature, and decreased anxiety, body mass and blood lipid levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    8
  • cDNA Data
    3
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15077 NCBI Gene Model | MGI Sequence Detail 664 C57BL/6J ±  kb
transcript NM_178216 RefSeq | MGI Sequence Detail 664 C57BL/6  
polypeptide P84228 UniProt | EBI | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1194885, MGI:3035157
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:7225 Sittman DB, et al., Structure of a cluster of mouse histone genes. Nucleic Acids Res. 1983 Oct 11;11(19):6679-97
  • Latest
    J:332290 Vetrivel S, et al., Identification of ocular regulatory functions of core histone variant H3.2. Exp Eye Res. 2022 Dec 15;226:109346
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory