Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr6a1tm2Coo
Name:	nuclear receptor subfamily 6, group A, member 1; targeted mutation 2, Austin J Cooney
MGI ID:	MGI:2448158
Synonyms:	GCNFlox
Gene:	Nr6a1  Location: Chr2:38613381-38816473 bp, - strand  Genetic Position: Chr2, 24.42 cM
Alliance:	Nr6a1tm2Coo page

Germline Transmission:	Earliest citation of germline transmission: J:80978
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The 243 bp exon encoding the DNA-binding domain was replaced by a single loxP site after cre mediated recombination within ES cells. A truncated protein, lacking the DNA-binding domain but retaining the downstream ligand-binding domain was detected by Western blot analysis of homozygous mutant mice. (J:80978)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr6a1 Mutation:	145 strains or lines available

Original:	J:80978 Lan ZJ, et al., The embryonic function of germ cell nuclear factor is dependent on the DNA binding domain. J Biol Chem. 2002 Dec 27;277(52):50660-7
All:	1 reference(s)