Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Clcn3tm1Lamb
Name:	chloride channel, voltage-sensitive 3; targeted mutation 1, Fred S Lamb
MGI ID:	MGI:2447864
Synonyms:	Clcn3-
Gene:	Clcn3  Location: Chr8:61363423-61436334 bp, - strand  Genetic Position: Chr8, 30.9 cM
Alliance:	Clcn3tm1Lamb page

Germline Transmission:	Earliest citation of germline transmission: J:80901
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encompassing a portion of exon 6 and all of exon 7 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded a portion of transmembrane domain 2 and all of transmembrane domains 3 and 4. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:80901)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn3 Mutation:	119 strains or lines available

Original:	J:80901 Dickerson LW, et al., Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels. Brain Res. 2002 Dec 27;958(2):227-50
All:	14 reference(s)