Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Gclmtm1Tdal
Name:	glutamate-cysteine ligase, modifier subunit; targeted mutation 1, Timothy P Dalton
MGI ID:	MGI:2447852
Synonyms:	Gclm(-), GCLM-
Gene:	Gclm  Location: Chr3:122039206-122060864 bp, + strand  Genetic Position: Chr3, 52.94 cM, cytoband H1-3
Alliance:	Gclmtm1Tdal page

Germline Transmission:	Earliest citation of germline transmission: J:80927
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. The 3' splice donor site of intron 1 was deleted and translation from either of the putative start codons is expected to terminate after 61 residues. Neither normal transcript nor normal protein was detected by Northern and Western blot analyses of liver and kidney tissue obtained from homozygous mutant mice. (J:80927)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gclm Mutation:	16 strains or lines available

Original:	J:80927 Yang Y, et al., Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(-/-) Knockout Mouse. NOVEL MODEL SYSTEM FOR A SEVERELY COMPROMISED OXIDATIVE STRESS RESPONSE. J Biol Chem. 2002 Dec 20;277(51):49446-52
All:	25 reference(s)