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Lin7atm1Dsb
Targeted Allele Detail
Summary
Symbol: Lin7atm1Dsb
Name: lin-7 homolog A, crumbs cell polarity complex component; targeted mutation 1, David S Bredt
MGI ID: MGI:2447803
Synonyms: MALS-1 KO
Gene: Lin7a  Location: Chr10:107107547-107257335 bp, + strand  Genetic Position: Chr10, 55.83 cM
Alliance: Lin7atm1Dsb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68187
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 39 amino acids. Western blot analysis of brain homogenates indicated an absence of protein in homozygous mutant mice. (J:68187)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lin7a Mutation:  22 strains or lines available
References
Original:  J:68187 Misawa H, et al., Contrasting localizations of mals/lin-7 pdz proteins in brain and molecular compensation in knockout mice. J Biol Chem. 2001 Mar 23;276(12):9264-72
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory