Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnj3tm1Kwn
Name:	potassium inwardly-rectifying channel, subfamily J, member 3; targeted mutation 1, Kevin D Wickman
MGI ID:	MGI:2447632
Synonyms:	GIRK1 KO, Kir3.1 knock-out
Gene:	Kcnj3  Location: Chr2:55325982-55488157 bp, + strand  Genetic Position: Chr2, 31.66 cM
Alliance:	Kcnj3tm1Kwn page

Germline Transmission:	Earliest citation of germline transmission: J:80714
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was deleted by homologous and cre mediated recombination in ES cells. The deleted sequence encoded the pore and transmembrane domains, the entire amino terminus, and the initiator methionine. Normal protein was undetected by Western blot analysis of atrial tissue obtained from homozygous mutant mice. (J:80714)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnj3 Mutation:	33 strains or lines available

Original:	J:80714 Bettahi I, et al., Contribution of the Kir3.1 Subunit to the Muscarinic-gated Atrial Potassium Channel IKACh. J Biol Chem. 2002 Dec 13;277(50):48282-8
All:	19 reference(s)