Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rnf2tm1Hko
Name:	ring finger protein 2; targeted mutation 1, Haruhiko Koseki
MGI ID:	MGI:2447529
Synonyms:	Ring1Bred
Gene:	Rnf2  Location: Chr1:151345149-151376747 bp, - strand  Genetic Position: Chr1, 64.15 cM
Alliance:	Rnf2tm1Hko page

Germline Transmission:	Earliest citation of germline transmission: J:79851
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: The authors generated a hypomorphic Rnf2 allele using gene targeting. No genomic sequence was deleted. However, a Neo cassette and 0.8 kb of one of the homology arms were inserted between exons 3 and 4. The inserted sequence was from 3' UTS. Protein levels in the homozygous mutant were 30% of those in the heterozygous mutant. (J:79851)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rnf2 Mutation:	36 strains or lines available

Original:	J:79851 Suzuki M, et al., Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development. 2002 Sep;129(18):4171-83
All:	2 reference(s)