Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Abcg2tm1Ahs
Name:	ATP binding cassette subfamily G member 2 (Junior blood group); targeted mutation 1, Alfred H Schinkel
MGI ID:	MGI:2447196
Synonyms:	Abcg2-, Bcrp1-
Gene:	Abcg2  Location: Chr6:58561476-58669436 bp, + strand
Alliance:	Abcg2tm1Ahs page

Germline Transmission:	Earliest citation of germline transmission: J:80519
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 5.1 kb genomic fragment encompassing exons 3 through 6 was replaced with a pgk-hygro selection cassette inserted by homologous recombination. The deleted region encoded the majority of the ATP-binding domain. The absence of normal transcript was confirmed by Northern blot analysis of homozygous mutant mice. No protein was detected by Western blot analysis or by immunohistochemical staining. (J:80519)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Abcg2tm1Ahs

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Abcg2 Mutation:	74 strains or lines available

Original:	J:80519 Jonker JW, et al., The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15649-54
All:	43 reference(s)