Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Blnktm1Pjln
Name:	B cell linker; targeted mutation 1, Peter J Nielsen
MGI ID:	MGI:2447161
Synonyms:	Slp65-, SLP-65-
Gene:	Blnk  Location: Chr19:40917371-40982664 bp, - strand  Genetic Position: Chr19, 34.26 cM
Alliance:	Blnktm1Pjln page

Germline Transmission:	Earliest citation of germline transmission: J:58740
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 4 and flanking intronic sequences with a neomycin resistance cassette. Northern blot analysis of splenocyte RNA revealed low levels of an aberrantly spliced transcript, however Western blot analysis detected no protein product. (J:58740)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Blnktm1Pjln

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Blnk Mutation:	76 strains or lines available

Original:	J:58740 Jumaa H, et al., Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity. 1999 Nov;11(5):547-54
All:	24 reference(s)