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Ccstm1Pcw
Targeted Allele Detail
Summary
Symbol: Ccstm1Pcw
Name: copper chaperone for superoxide dismutase; targeted mutation 1, Philip C Wong
MGI ID: MGI:2446505
Synonyms: CCS-
Gene: Ccs  Location: Chr19:4875394-4889326 bp, - strand  Genetic Position: Chr19, 4.11 cM
Alliance: Ccstm1Pcw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80627
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.5 kb genomic fragment containing the first two exons, part of the promoter, and the first two introns of the gene was replaced with a neomycin selection cassette inserted by homologous recombination. No protein was detected by Western blot analysis of homozygous mutant mice. (J:80627)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccs Mutation:  25 strains or lines available
References
Original:  J:80627 Wong PC, et al., Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2886-91
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory