Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hcsttm1.1Cln
Name:	hematopoietic cell signal transducer; targeted mutation 1.1, Marco Colonna
MGI ID:	MGI:2446491
Synonyms:	DAP10-
Gene:	Hcst  Location: Chr7:30117137-30119279 bp, - strand  Genetic Position: Chr7, 17.45 cM
Alliance:	Hcsttm1.1Cln page

Germline Transmission:	Earliest citation of germline transmission: J:80426
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: This allele is derived from Hcsttm1Cln by mating mutant animals to cre deleter strain TgN(CMV-cre)1Cgn. Resulting progeny are deleted for the floxed neo cassette and contain a single loxP site in place of exon 1 and intron 1. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of lysates from NK cells and CD8+ cells. (J:80426)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcst Mutation:	9 strains or lines available

Original:	J:80426 Gilfillan S, et al., NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002 Dec;3(12):1150-5
All:	22 reference(s)