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Mosmo Gene Detail
Summary
  • Symbol
    Mosmo
  • Name
    modulator of smoothened
  • Synonyms
    BC030336, MGC:40669
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446240
    NCBI Gene: 233812
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:120276841-120334077 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    318 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446240
 protein coding gene Chr7:120276825-120334077 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032932
 protein coding gene Chr7:124661180-124724345 (+)
A/J MGP_AJ_G0032915
 protein coding gene Chr7:121419384-121477856 (+)
AKR/J MGP_AKRJ_G0032847
 protein coding gene Chr7:124537761-124596851 (+)
BALB/cJ MGP_BALBcJ_G0032920
 protein coding gene Chr7:121140403-121198908 (+)
C3H/HeJ MGP_C3HHeJ_G0032630
 protein coding gene Chr7:124441653-124501120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033426
 protein coding gene Chr7:129616304-129678170 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030398
 protein coding gene Chr7:122806549-122866377 (+)
CAST/EiJ MGP_CASTEiJ_G0031958
 protein coding gene Chr7:116197240-116262174 (+)
CBA/J MGP_CBAJ_G0032603
 protein coding gene Chr7:133934907-133996548 (+)
DBA/2J MGP_DBA2J_G0032755
 protein coding gene Chr7:119460848-119519446 (+)
FVB/NJ MGP_FVBNJ_G0032708
 protein coding gene Chr7:119317298-119377492 (+)
LP/J MGP_LPJ_G0032849
 protein coding gene Chr7:126104670-126174588 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032740
 protein coding gene Chr7:135407018-135465292 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033446
 protein coding gene Chr7:123525556-123583650 (+)
PWK/PhJ MGP_PWKPhJ_G0031666
 protein coding gene Chr7:112388201-112446930 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031512
 protein coding gene Chr7:110272803-110343437 (+)
WSB/EiJ MGP_WSBEiJ_G0032071
 protein coding gene Chr7:124451509-124512052 (+)



Homology
more
  • Human Ortholog
    MOSMO, modulator of smoothened
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOSMO, modulator of smoothened
  • Synonyms
    ATTHOG, BC030336, C16orf52
  • Links
    NCBI Gene ID: 730094
    neXtProt AC: NX_Q8NHV5
    UniProt: Q8NHV5

  • Chr Location
    16p12.2; chr16:22007638-22092652 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit severe developmental defects, including heterotaxy, skeletal abnormalities and congenital heart defects and most die by E14.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    7
  • cDNA Data
    40
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046096 Ensembl Gene Model | MGI Sequence Detail 57237 C57BL/6J ±  kb
    transcript ENSMUST00000060175 Ensembl | MGI Sequence Detail 4831 Not Applicable  
    polypeptide ENSMUSP00000055934 Ensembl | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 40
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:311933 Kong JH, et al., Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development. 2021 Oct 1;148(19):dev199867
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory